DNA Vaccines Against Mycoplasma Elicit Humoral Immune Responses in Ostriches

Against HIV at Systemic and Mucosal Sites Elicit Multifaceted Immune Responses Immunostimulatory DNA-Based Vaccines

DNA-encapsulated magnesium phosphate nanoparticles elicit both humoral and cellular immune responses in mice

The efficacy of pEGFP (plasmid expressing enhanced green fluorescent protein)-encapsulated PEGylated (meaning polyethylene glycol coated) magnesium phosphate nanoparticles (referred to as MgPi-pEGFP nanoparticles) for the induction of immune responses was investigated in a mouse model. MgPi-pEGFP nanoparticles induced enhanced serum antibody and antigen-specific T-lymphocyte responses, as well ...

th۱ platform immune responses against leishmania major induced by thiol-specific antioxidant-based dna vaccines

background: the thiol-specific antioxidant (tsa) is an antigen of leishmania major which is believed to be the most promising molecule as a vaccine candidate against leishmaniasis. objectives: in this study, we investigated the protective efficacy of tsa-based dna vaccine against l. major infection. materials and methods: recombinant plasmid construction tsa (pctsa) was prepared and transfected...

Immune efficacy of OmpH and OmpA DNA vaccines against avian Pasteurella multocida

Avian Pasteurella multocida is an agent of fowl cholera. The protective effect achieved through orthodoxvaccines is not ideal. The research on novel vaccines against avian Pasteurella multocida is imperative. Inthis study, the genes encoding outer membrane protein H and A (OmpH and OmpA) were cloned into theeukaryotic expression vector pcDNA3.1(+) and the recombinant plasmids, namely DNA vaccin...

Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates.

The magnitude and durability of immune responses induced by replication-defective adenovirus serotype 5 (ADV5) vector-based vaccines were evaluated in the simian-human immunodeficiency virus/rhesus monkey model. A single inoculation of recombinant ADV5 vector constructs induced cellular and humoral immunity, but the rapid generation of neutralizing anti-Ad5 antibodies limited the immunity induc...